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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TRPV4 All Species: 22.12
Human Site: S422 Identified Species: 60.83
UniProt: Q9HBA0 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HBA0 NP_067638.3 871 98281 S422 Y S S L Y D L S S L D T C G E
Chimpanzee Pan troglodytes XP_001170188 764 85825 V338 W C Y G P V R V S L Y D L A S
Rhesus Macaque Macaca mulatta XP_001098148 722 82073 R297 Y N S K I E N R H E M L A V E
Dog Lupus familis XP_546641 742 82829 R317 I F R H I L Q R E F S G P C Q
Cat Felis silvestris
Mouse Mus musculus Q9EPK8 871 98008 S422 Y S S L Y D L S S L D T C G E
Rat Rattus norvegicus Q9ERZ8 871 97991 S422 Y S S L Y D L S S L D T C G E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508791 846 96380 S392 H S S L Y D L S C I D T C E K
Chicken Gallus gallus NP_990023 852 96180 S408 Y S S L Y D L S S L D T C G E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001036195 841 95517 S414 Y S N L Y D L S S L D T C G E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40.2 80.8 40 N.A. 95.2 94.8 N.A. 45.8 84 N.A. 69.4 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 55.5 81.7 54.8 N.A. 97.5 97.3 N.A. 63.3 90.8 N.A. 80 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 13.3 20 0 N.A. 100 100 N.A. 66.6 100 N.A. 93.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 20 33.3 6.6 N.A. 100 100 N.A. 86.6 100 N.A. 100 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 12 12 0 % A
% Cys: 0 12 0 0 0 0 0 0 12 0 0 0 67 12 0 % C
% Asp: 0 0 0 0 0 67 0 0 0 0 67 12 0 0 0 % D
% Glu: 0 0 0 0 0 12 0 0 12 12 0 0 0 12 67 % E
% Phe: 0 12 0 0 0 0 0 0 0 12 0 0 0 0 0 % F
% Gly: 0 0 0 12 0 0 0 0 0 0 0 12 0 56 0 % G
% His: 12 0 0 12 0 0 0 0 12 0 0 0 0 0 0 % H
% Ile: 12 0 0 0 23 0 0 0 0 12 0 0 0 0 0 % I
% Lys: 0 0 0 12 0 0 0 0 0 0 0 0 0 0 12 % K
% Leu: 0 0 0 67 0 12 67 0 0 67 0 12 12 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 12 0 0 0 0 % M
% Asn: 0 12 12 0 0 0 12 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 12 0 0 0 0 0 0 0 12 0 0 % P
% Gln: 0 0 0 0 0 0 12 0 0 0 0 0 0 0 12 % Q
% Arg: 0 0 12 0 0 0 12 23 0 0 0 0 0 0 0 % R
% Ser: 0 67 67 0 0 0 0 67 67 0 12 0 0 0 12 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 67 0 0 0 % T
% Val: 0 0 0 0 0 12 0 12 0 0 0 0 0 12 0 % V
% Trp: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 67 0 12 0 67 0 0 0 0 0 12 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _